Metabolism is a complicated process that converts food into fuel for your body to use. When you experience metabolic disorders, such as leucine metabolism, it could be caused by a sudden change in enzyme activity, a substance deficiency that prevents proper activity of enzymes or a problem with transporting compounds. These kinds of disorders can become serious if not treated properly.
When you suffer from metabolism disorders, you have to follow diet changes, which are based from the type of disorder. For instance, a leucine metabolism disorder should be treated by providing the necessary leucine or inactivity of this substance to correct your metabolism. A professional dietician can help you in developing a diet plan to ensure all your body’s needs are met to regulate metabolism.
Disorders Of Leucine Metabolism
Valine, isoleucine and leucine are three branched-chain amino acids. When the enzymes involved in the metabolism of any of these amino acids become deficient, it could lead to a build-up of organic acids.
There are several disorders associated with leucine metabolism. One of them is known as “maple syrup urine disease”. This condition occurs when high plasma levels of leucine metabolism are found in the body. A body fluid odor resembling maple syrup may show up during clinical tests. Maple syrup urine disease is rare, but can become serious and even lead to death if left untreated.
Make sure to seek medical supervision because your condition could cause lethargy and vomiting, which could lead to seizures and coma. Since the maple syrup disease involves high levels of leucine metabolism, the treatment may involve restrictions from dietary leucine and other branched-chain amino acids. However, your diet may include a small amount of these amino acids to allow regular metabolic functions of your body.
Another disease involving branched-chain amino acids is called “isovaleric acidemia". The third step involved in leucine metabolism is the dehydrogenation process or transforming isovaleryl CoA into 3-methlcrotonyl CoA. When the process fails and causes a deficiency in 3-methylcrotonyl CoA, it causes “isovaleric acidemia". This condition is also referred to as “sweaty feet” because people with this disorder emit a certain smell similar to sweat.
Sweaty feet may cause vomiting, respiratory problems, hypoglycemia and other serious conditions. When you are diagnosed with sweaty feet disorder, you may have to undergo a long-term restriction of dietary leucine. However, supplementation of carnitine and glycine is important.
Metabolic imbalances can be treated through medically supervised nutrition plans. When diagnoses with a leucine metabolism disorder, your doctor should determine whether you need more or less of leucine in your diet to ensure balance absorption of nutrients in the body.
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